| 摘要 |
<p>This invention relates to the role of the outer membrane protein OmpATb in the virulence of Mycobacteria such as M. tuberculosis. The OmpATb protein is shown to be a virulence factor which allows growth in acidic environments. Mycobacterium OmpATb mutants, particularly mutants of mycobacteria which are members of the Mycobacterium tuberculosis complex, such as BCG and M. tuberculosis, are shown to be useful as immunotherapeutic agents, vaccines, or carriers for use in generating new vaccines, for example in the treatment of a range of disorders, including tuberculosis.</p> |
