The present invention relates to genetic markers whose expression is correlated with breast cancer. Specifically, the invention provides sets of markers whose expression patterns can be used to differentiate clinical conditions associated with breast cancer, such as the presence or absence of the estrogen receptor ESR1, and BRCA1 and sporadic tumors, and to provide information on the likelihood of tumor distant metastases within five years of initial diagnosis. The invention relates to methods of using these markers t o distinguish these conditions. The invention also relates to kits containing ready-to-use microarrays and computer software for data analysis using the statistical methods disclosed herein.
申请公布号
CA2451074(A1)
申请公布日期
2002.12.27
申请号
CA20022451074
申请日期
2002.06.14
申请人
ROSETTA INPHARMATICS, INC.
发明人
LINSLEY, PETER S.;BERNARDS, RENE;HART, A. A. M.;ROBERTS, CHRISTOPHER J.;MAO, MAO;VAN'T VEER, LAURA JOHANNA;VAN DE VIJVER, MARC J.;HE, YUDONG;DAI, HONGYUE