2-ADAMANTYL-4,6-DIAMINO-1,2-DIHYDRO-1-ARYL-1,3,5-TRIAZINE DERIVATIVES AS CELL PROLIFIRATION INHIBITORS

摘要

A series of new 4,6-diamino-1,2-dihydro-1-aryl-2-(1-tricyclo[3.3.1.13,7] decyl]-1,3,5-triazines where the aryl group is a subst ituted or unsubstitut ed phenyl, or naphthyl- group, as pharmaceutically accepted salts or as free bases.The phenyl group substituents are halides, alkyls, alkoxyls or nitro group. One or more of the above substituents are found one or more times eac h one, and in various positions of the phenyl group.The corresponding isomers, stereoisomers, enantiomers, free bases and their complexes with various natural macromolecules and synthetic derivatives of them.The invention refer s to new and prototype compounds inhibiting the proliferation of unwanted cell s that belong to pathogenic microorganisms, to human tissues, to pathological cells, or any pathological cell proliferation. It also refers to the synthes is and the method of synthesis of the above mentioned compounds.The synthesis a nd the method of synthesis thereof of a series characterized by the preparation of the final triazines, by cyclization of the bigouanide hydrochlorides with adamantane-1-carboxaldehyde. Preparation of the inclusion complexes is realized from compexation of the corresponding hydrochlorides of the above mentioned triazines with natural macromolecules or synthetic derivatives.