发明名称 |
A NOVEL SIGNALING PATHWAY FOR THE PRODUCTION OF INFLAMMATORY PAIN AND NEUROPATHY |
摘要 |
This invention pertains to the discovery of a novel pathway that mediates hyperalgesia, neuropathic pain, and inflammatory pain. This pathway is a third independent pathway that involves activation of extracellular signal-regulated kinases (ERKs) 1 and 2. The pathway comprises a Ras-MEK-ERK1/2 cascade that acts independent of PKA or PKC epsilon as a novel signaling pathway for the production of inflammatory (and neuropathic) pain. This pathway presents numerous targets for a new class of analgesic agents. |
申请公布号 |
WO02102232(A2) |
申请公布日期 |
2002.12.27 |
申请号 |
WO2002US19107 |
申请日期 |
2002.06.14 |
申请人 |
THE REGENTS OF THE UNIVERSITY OF CALIFORNIA;LEVINE, JON DAVID;MESSING, ROBERT O. |
发明人 |
LEVINE, JON DAVID;MESSING, ROBERT O. |
分类号 |
A61K31/00;A61K38/16;A61K38/45;A61K45/06;C12Q1/48;G01N33/50 |
主分类号 |
A61K31/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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