A SELECTABLE GENETIC MARKER FOR USE IN PASTEURELLACEAE SPECIES
摘要
The present invention provides a nucleic acid encoding nicotinamide phosphoribosyltransferase (NadV) from a V-factor independent bacterium and provides methods for using the gene as a selection marker for constructing recombinant bacteria from V-factor dependent bacteria. The method is an improvement over methods which rely on nucleic acids which confer antibiotic resistance for constructing recombinant bacteria. Methods for constructing attenuated recombinant <i>(Actinobacillus pleuropneumoniae)</i> using the selection method of the present invention are also provided.
申请公布号
WO0238733(B1)
申请公布日期
2002.12.27
申请号
WO2001US46804
申请日期
2001.11.08
申请人
MICHIGAN STATE UNIVERSITY;MULKS, MARTHA, H.;MARTIN, PAUL, R.;SHEA, ROBIN, J.
发明人
MULKS, MARTHA, H.;MARTIN, PAUL, R.;SHEA, ROBIN, J.