NOVEL PYRAZOLOPYRIMIDINETHIONE DERIVATIVES. PREPARATION METHODS THEREOF AND THEIR USE AS THERAPEUTICS FOR ERECTILE DYSFUNCTION

摘要

Novel pyrazolopyrimidinethione compounds of formula 1: wherein R1 and R2 are independently each hydrogen atom, a C1-C6 alkyl group, or a C3-C6 cycloalkyl group, R3 is a C1-C6 alkyl group, C3-C6 cycloalkyl group or C3-C6 alkenyl group which is substituted or unsubstituted, X is O or NR4, and R4 is hydrogen atom, or a C1-C6 alkyl group, a C3-C6 cycloalkyl group or a C3-C6 alkenyl group which is unsubstituted or substituted with OH or an alkoxy group, pharmacologically acceptable salts or hydrates thereof, and preparation methods thereof are disclosed. Pharmaceutical compositions comprising the compounds are effectively used for the treatment of erectile dysfunction.