<i>MORAXELLA BOVIS</i> CYTOTOXIN, CYTOTOXIN GENE, ANTIBODIES AND VACCINES FOR PREVENTION AND TREATMENT OF <i>MORAXELLA BOVIS</i> INFECTIONS

摘要

Moraxella bovis cytotoxin and a gene encoding Moraxella bovis. Identification, isolation, cloning and identification of nucleotide sequence of the Moraxella bovis genes mbxA, mbxB, mbxC and mbxD, partial purification of the native cytotoxin, preparation of partially purified native and a recombinant Moraxella bovis cytotoxin, identification of an amino acid sequence of the cytotoxin, preparation of antibodies against the Moraxella bovis cytotoxin, preparation of vaccines against Moraxella bovis. Method for prevention and treatment of infectious bovine keratoconjunctivitis caused by Moraxella bovis.