发明名称 |
AMINE SALT OF AN INTEGRIN RECEPTOR ANTAGONIST |
摘要 |
The tris(hydroxymethyl)aminomethane ("TRIS") salt of 3-(pyrimidin-5-yl)-9-(5,6,7,8-tetrahydro-[1,8]-naphthyridin-2-yl)-nona noic acid is a potent antagonist of the integrin alpha v beta 3 receptor and is useful for the prevention and/or treatment of osteoporosis and vascular restenosis, as well as conditions associated with excessive angiogenesis, such as macular degeneration, diabetic retinopathy, atherosclerosis, inflammatory arthritis, cancer, and metastatic tumor growth. The invention also relates to a process for the preparation of the novel salt as well as pharmaceutical compositions containing the salt and methods of using the salt.
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申请公布号 |
WO02102374(A1) |
申请公布日期 |
2002.12.27 |
申请号 |
WO2002US18906 |
申请日期 |
2002.06.14 |
申请人 |
MERCK & CO., INC.;HUMPHREY, GUY, R.;XU, WEI |
发明人 |
HUMPHREY, GUY, R.;XU, WEI |
分类号 |
C07D471/04;(IPC1-7):A61K31/407 |
主分类号 |
C07D471/04 |
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