发明名称 |
(PYRIDO/THIENO)-[f]-OXAZEPIN-5-ONE DERIVATIVES |
摘要 |
The present invention relates to (pyrido/thieno)-[f]-oxazepine-5-one derivatives having the general Formula I wherein R<1>, R<2> and R<3> are independently H or (C1-4)alkyl; Ar represents a fused thiophene or pyridine ring optionally substituted with one or more substituents selected from (C1-4)alkyl, (C1-4)alkyloxy, (C1-4)alkyloxy(C1-4)alkyl, CF3, halogen, nitro, cyano, NR<4>R<5>, NR<4>COR<6>, and CONR<4>R<5>; R<4> and R<5> are independently H or (C1-4)-alkyl; or R<4> and R<5> form together with the nitrogen atom to which they are bound a 5-or 6-membered saturated heterocyclic ring, optionally containing a further heteroatom selected from O, S or NR<6>; R<6> is (C1-4)alkyl; A represents the residue of a 4-7 membered saturated heterocyclic ring, optionally containing an oxygen atom, the ring being optionally substituted with 1-3 substituents selected from (C1-4)alkyl, (C1-4)-alkyloxy, hydroxy, halogen and oxo; or a pharmaceutically acceptable salt thereof. The invention also relates to pharmaceutical compositions comprising said derivatives, and to the use of these (pyrido/thieno)-[f]-oxazepine-5-one derivatives in the treatment of neurological diseases and psychiatric disorders which are responsive to enhancement of synaptic responses mediated by AMPA receptors in the central nervous system. |
申请公布号 |
WO02102808(A2) |
申请公布日期 |
2002.12.27 |
申请号 |
WO2002EP06364 |
申请日期 |
2002.06.10 |
申请人 |
AKZO NOBEL N.V.;GROVE, SIMON, JAMES, ANTHONY;ADAM-WORRALL, JULIA;ZHANG, MINGQIANG;GILFILLAN, ROBERT |
发明人 |
GROVE, SIMON, JAMES, ANTHONY;ADAM-WORRALL, JULIA;ZHANG, MINGQIANG;GILFILLAN, ROBERT |
分类号 |
A61K31/553;A61P9/00;A61P15/10;A61P17/02;A61P25/00;A61P25/08;A61P25/18;A61P25/22;A61P25/24;A61P25/28;A61P25/30;A61P25/32;A61P43/00;C07D498/14 |
主分类号 |
A61K31/553 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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