| 发明名称 |
NEW USE OF SPECIFIC CYCLOLIGNANS |
| 摘要 |
The invention refers to the use of specific cyclolignans, wherein the carbon atoms in positions 9 and 9' have cis configuration, for inhibition of the insulin-like growth factor-1 receptor. Said compounds can be used for treatment of IGF-1R dependent diseases, such as cancer, psoriasis, artherosclerosis and acromegaly. A preferred compound is picropodophyllin. |
| 申请公布号 |
WO02102804(A1) |
申请公布日期 |
2002.12.27 |
| 申请号 |
WO2002SE01202 |
申请日期 |
2002.06.19 |
| 申请人 |
KAROLINSKA INNOVATIONS AB;LARSSON, OLLE;AXELSON, MAGNUS |
发明人 |
LARSSON, OLLE;AXELSON, MAGNUS |
| 分类号 |
A61K31/34;A61K31/36;A61K31/365;A61P5/06;A61P9/10;A61P17/06;A61P35/00;A61P35/02;A61P43/00;C07D317/54;C07D317/70;C07D493/04 |
主分类号 |
A61K31/34 |
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