METHODS AND COMPOSITIONS BASED ON PROTEIN INTERACTIONS WITH MASTERMIND

摘要

The invention is directed to methods of modulating Notch signal transduction and to complexes of the protein Mastermind with proteins identified as interacting with Mastermind by a two-hybrid screen as well as a complex ofMastermind (Mam) with Mipl, or a complex ofMam with Mip30, or a complex ofMam with Mip6. Methods of screening the complexes for efficacy in treating and/or preventing certain diseases and disorders, particularly hyperproliferative and cancerous conditions are also provided. The invention includes nucleic acid and amino acid sequences of Mip30 or Mip6, as well as fragments and derivatives thereof.