MUTATIONS IN THE BCR-ABL TYROSINE KINASE ASSOCIATED WITH RESISTANCE TO STI-571

摘要

The invention described herein relates to novel genes and their encoded proteins, termed Mutants Associated withResistance to STI-571 (e.g.,T315I Bc r- Abl), and to diagnostic and therapeutic methods and compositions useful in t he management of various cancers that express MARS. The invention further provides methods for identifying molecules that bind to and/or modulate the functional activity of MARS.