SUBSTITUTED BIARYL COMPOUNDS OR SUBSTITUTED PYRIDINES AND PHARMACEUTICAL COMPOSITIONS BASED ON THEREOF

摘要

FIELD: organic chemistry, medicine, endocrinology, pharmacy. SUBSTANCE: invention relates to biaryl compounds or substituted pyridines of the formula (I) where X means N or CR8 where R8 means hydrogen atom, halogen atom, phenyl, alkyl, alkoxy-group, alkoxycarbonyl, carboxy-group, formyl or -NR4R5 where R4 and R5 mean hydrogen atom, alkyl, alkenyl, cycloalkyl, phenyl, naphthyl; R1a and R1Ô mean trifluoromethyl, alkyl, alkenyl, alkynyl, cycloalkyl, alkanoyl; R2 means alkyl, alkenyl, alkynyl, cycloalkyl; R3 means hydroxy-group, trifluoroacetyl, alkanoyl, alkenyl; Ar means aromatic or heteroaromatic ring, for example, phenyl, naphthyl, pyridyl, furanyl, thiophenyl. Compounds of the formula (I) show antagonistic effect with respect to glucagon receptor and can be used in treatment of glucagons-mediated states, for example, diabetes mellitus. EFFECT: valuable medicinal properties of compounds. 20 cl, 2 tbl