SIR2 alpha -BASED THERAPEUTIC AND PROPHYLACTIC METHODS

摘要

This invention provides methods for treating and for inhibiting the onset of cancer in a subject comprising administering an agent that inhibits the ability of Sir2 alpha to inhibit p53-dependent apoptosis. This invention also provides a related method for inducing the death of a cell. This invention further provides a method for decreasing the amount of damage to ta subject's cells caused by physical stress comprising administering agent that increases the amount of Sir2 alpha in the subject's cells and/or the ability of Sir2 alpha to inhibit p53-dependent apoptosis in the subject's cells. This invention further provides related methods for prolonging the life-span of a subject, decreasing the amount of damage to a cell caused by physical stress, and prolonging the life-span of a cell. Finally, this invention provides two articles of manufacture for performing the instant methods.