GASTRIC FLOATING SYSTEM

摘要

A solid controlled release oral, buoyant unit dose pharmaceutical composition, which comprises of one or more therapeutic agent/drug, a gel forming husk powder obtained from Lepidium Sativum seeds, one or more cross-linking enhancer, one or more gas generating component and pharmaceutically acceptable excipients. The gel forming husk powder obtained from Lepidium sativum seeds is present in amounts of between 5 to 60 % of the total weight of dosage form, the cross-linking enhancer is selected from xanthan gum, karaya gum and the like in amounts of from 0.5 to 10 % by weight of the dosage form, gas generating component in amounts of from about 5 % to 20 % by weight of the composition to give a release profile of between 4 to 12 hours. The total excipients added is between 10 to 40 % by weight of the total dosage form. The composition may be in the form of a tablet capsules and pallets. The therapeutic agent/drug used in the composition is selected from drugs that are absorbed predominantly from the upper parts of gastrointestinal tract.