| 发明名称 |
Chimeric proteins |
| 摘要 |
Chimeric proteins possessing Kunitz-type domain 1 of TFPI-2 and Kunitz-type domain 2 of TFPI are disclosed, as are muteins of TFPI and TFPI-2. Nucleic acid sequences, expression vectors and transformed host cells encoding and capable of producing the disclosed chimeric proteins and muteins are also disclosed. Finally, methods for prevention and treatment of septic shock using the chimeric proteins and muteins are disclosed.
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| 申请公布号 |
US2002197667(A1) |
申请公布日期 |
2002.12.26 |
| 申请号 |
US20000741106 |
申请日期 |
2000.12.21 |
| 申请人 |
INNIS MICHAEL A.;CREASEY ABLA A. |
发明人 |
INNIS MICHAEL A.;CREASEY ABLA A. |
| 分类号 |
C12N15/09;A61K38/00;A61K38/55;A61K39/395;A61P7/02;A61P31/04;C07K14/81;C07K16/38;C07K19/00;C12N1/19;C12N15/15;C12P21/02;C12P21/08;(IPC1-7):C12N9/00;C07H21/04;C12N5/06 |
主分类号 |
C12N15/09 |
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