| 发明名称 |
Novel farnesyl protein transferase inhibitors as antitumor agents |
| 摘要 |
The present invention discloses novel tricyclic compounds represented by the formula (1.0): a prodrug thereof, or a pharmaceutically acceptable salt or solvate of the compound or of said prodrug useful for inhibiting farnesyl protein transferase. Also disclosed are pharmaceutical compositions comprising such compounds their preparation as well as methods of using them to treat proliferative diseases such as cancer.
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| 申请公布号 |
US2002198216(A1) |
申请公布日期 |
2002.12.26 |
| 申请号 |
US20010940811 |
申请日期 |
2001.08.28 |
| 申请人 |
NJOROGE F. GEORGE;VIBULBHAN BANCHA;COOPER ALAN B.;GUZI TIMOTHY;RANE DINANATH F.;MINOR KEITH P.;DOLL RONALD J.;GIRIJAVALLABHAN VIYYOOR M.;SANTHANAM BAMA;PINTO PATRICK A.;ZHU HUGH Y.;KEERTIKAR KARTIK M.;ALVAREZ CARMEN S.;BALDWIN JOHN J.;LI GE;HUANG CHIA-YU;JAMES RAY A.;BISHOP W. ROBERT;WANG JAMES J-S;DESAI JAGDISH A. |
发明人 |
NJOROGE F. GEORGE;VIBULBHAN BANCHA;COOPER ALAN B.;GUZI TIMOTHY;RANE DINANATH F.;MINOR KEITH P.;DOLL RONALD J.;GIRIJAVALLABHAN VIYYOOR M.;SANTHANAM BAMA;PINTO PATRICK A.;ZHU HUGH Y.;KEERTIKAR KARTIK M.;ALVAREZ CARMEN S.;BALDWIN JOHN J.;LI GE;HUANG CHIA-YU;JAMES RAY A.;BISHOP W. ROBERT;WANG JAMES J-S;DESAI JAGDISH A. |
| 分类号 |
C07D233/61;A61K31/4545;A61K31/496;A61K31/5377;A61K31/5513;A61K45/00;A61P35/00;A61P43/00;C07D221/16;C07D401/04;C07D401/06;C07D401/10;C07D401/14;C07D405/06;C07D409/06;C07D409/12;C07D413/06;C07D413/12;C07D521/00;(IPC1-7):A61K31/496;A61K31/473;C0743/14 |
主分类号 |
C07D233/61 |
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