| 发明名称 |
Glial cell line-derived neurotrophic factor |
| 摘要 |
A novel neurotrophic factor referred to as glial derived neurotrophic factor (GDNF) has been identified and isolated from serum free growth conditioned medium of B49 glioblastoma cells. Rat and human genes encoding GDNF have been cloned and sequenced. A gene encoding GDNF has been subcloned into a vector, and the vector has been used to transform a host cell in order to produce biologically active GDNF in a recombinant DNA process.
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| 申请公布号 |
US2002197675(A1) |
申请公布日期 |
2002.12.26 |
| 申请号 |
US20010991119 |
申请日期 |
2001.11.13 |
| 申请人 |
AMGEN INC. |
发明人 |
LIN LEU-FEN H.;COLLINS FRANKLIN D.;DOHERTY DANIEL H.;LILE JACK;BEKTESH SUSAN |
| 分类号 |
A61K38/00;A61K9/00;A61K9/22;A61K31/00;A61K39/395;A61M37/00;A61P25/00;A61P25/16;A61P25/26;A61P25/28;C07K1/20;C07K1/22;C07K14/47;C07K14/475;C07K14/52;C07K16/00;C07K16/24;C12N;C12N1/21;C12N5/02;C12N5/10;C12N15/09;C12N15/12;C12P21/02;C12P21/08;C12R1/19;C12R1/91;(IPC1-7):A61K38/00;C07K1/00;C07K17/00;C07K14/00;C12N5/00;C12N15/74;C12N15/70;C12N15/63;C12N15/00;C12P21/06;C07H21/04 |
主分类号 |
A61K38/00 |
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