Non-human animal exhibiting bone metastasis of tumor cells and method of screening for bone metastasis inhibitors

摘要

The present invention provides a non-human bone metastasis model animal in which tumor cells capable of inducing bone metastasis by peripheral administration have been introduced, and a method for producing the animal. The bone metastasis model animal in the present invention may be useful for understanding the biology of bone metastasis and developing novel therapeutic strategies for lung cancer patient with multi-organ metastases, including bone metastasis. The present invention also provides a method of screening an agent for inhibition and/or prevention of bone metastasis of tumor cells using the non-human bone metastasis model animal.