发明名称 |
Immunogenic compositions for induction of anti-tumor immunity |
摘要 |
The invention relates to the use of an immunogen selected from the group consisting of (i) an anti-p53 mAb; (ii) a fragment of an anti-p53 mAb; (iii) a peptide based on a CDR of the heavy or light chain of an anti-p53 mAb, which peptide is capable of eliciting antibodies to p53; and (iv) a DNA molecule coding for the variable (V) region of an anti-p53 mAb in a suitable gene delivery vehicle, for the preparation of a pharmaceutical composition useful for induction of anti-tumor immunity in mammals, for activating an enhanced immune response to a p53 molecule in mammals, and/or for induction of immune responses to mutated and wild-type forms of a p53 in mammals. The use of anti-p53 mAbs and novel peptides based on the CDR2 and CDR3 of the heavy chains and CDR3 of the light chains of different anti-p53 mAbs are disclosed.
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申请公布号 |
US2002197270(A1) |
申请公布日期 |
2002.12.26 |
申请号 |
US20020032482 |
申请日期 |
2002.01.02 |
申请人 |
YEDA RESEARCH AND DEVELOPMENT CO. LTD. |
发明人 |
COHEN IRUN R.;ROTTER VARDA;WOLKOWICZ ROLAND;RUIZ PEDRO;EREZ-ALON NETA;HERKEL JOHANNES |
分类号 |
A61K39/00;A61K48/00;A61P35/00;A61P37/04;C07K16/18;C07K16/30;(IPC1-7):A61K48/00 |
主分类号 |
A61K39/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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