| 发明名称 |
Aryldifluoromethylphosphonic acids with sulfur-containing substituents as PTP-1B inhibitors |
| 摘要 |
The invention encompasses the novel class of compounds represented by the formula below, which are inhibitors of the PTP-1B enzyme.The invention also encompasses pharmaceutical compositions and methods of treating or preventing PTP-1B mediated diseases, including diabetes.
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| 申请公布号 |
US6498151(B2) |
申请公布日期 |
2002.12.24 |
| 申请号 |
US20010813489 |
申请日期 |
2001.03.21 |
| 申请人 |
MERCK FROSST CANADA & CO. |
发明人 |
LI CHUN SING;BAYLY CHRISTOPHER;GAUTHIER JACQUES YVES;LEBLANC YVES;LAU CHEUK KUN;ROY PATRICK;THERIEN MICHEL;WANG ZHAOYIN;DUFRESNE CLAUDE;FORTIN REJEAN |
| 分类号 |
A61K45/00;A61K31/10;A61K31/137;A61K31/365;A61K31/437;A61K31/4406;A61K31/455;A61K31/64;A61K31/66;A61K31/662;A61K31/663;A61K38/28;A61K45/06;A61P1/00;A61P1/04;A61P1/18;A61P3/04;A61P3/06;A61P3/10;A61P5/48;A61P9/08;A61P9/10;A61P25/00;A61P25/28;A61P29/00;A61P35/00;A61P43/00;C07F9/38;C07F9/40;C07F9/553;C07F9/572;C07F9/576;C07F9/58;C07F9/59;C07F9/60;C07F9/6506;C07F9/6512;C07F9/6518;C07F9/6524;C07F9/653;C07F9/6539;C07F9/655;C07F9/6558;(IPC1-7):C07D239/95;C07D277/36;A61K31/675 |
主分类号 |
A61K45/00 |
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