发明名称 |
2,3-olefinic epothilone derivatives |
摘要 |
The present invention relates to 2,3-position modified epothilone derivatives, methods of preparation of the derivatives, and intermediates therefor. The compounds of the invention as 16-membered macrolides having the general structure,which have microtubule-stabilizing effects and cytotoxic activity against rapidly proliferating cells, such as, tumor cells or other hyperproliferative cellular disease.
|
申请公布号 |
US6498257(B1) |
申请公布日期 |
2002.12.24 |
申请号 |
US19990280210 |
申请日期 |
1999.03.29 |
申请人 |
BRISTOL-MYERS SQUIBB COMPANY |
发明人 |
VITE GREGORY D.;BORZILLERI ROBERT M.;HOEFLE GERHARD;LEIBOLD THOMAS |
分类号 |
C07D491/044;A61K31/427;A61K31/438;A61K31/5513;A61K31/5517;A61P35/00;C07D277/30;C07D417/06;C07D491/04;C07D493/04;(IPC1-7):C07D277/30 |
主分类号 |
C07D491/044 |
代理机构 |
|
代理人 |
|
主权项 |
|
地址 |
|