CONDITIONAL KNOCKOUT MAMMAL HAVING INACTIVATED SPHINGOLIPID SYNTHETIC ACTIVITY

摘要

PROBLEM TO BE SOLVED: To provide a conditional knockout mammal having inactivated sphingolipid synthetic activity. SOLUTION: The conditional knockout mammal is prepared by partially or totally inactivating the synthetic activity of sphingolipid in time-specific and/or tissue-specific state by modifying a part or total of the DNA region of serine palmitoyl transferase gene in the genom.