发明名称 |
Method for treating cytokine mediated hepatic injury. |
摘要 |
A method of modulating cytokine mediated hepatic injury by administering deltorphins to a mammal. Deltorphin I SEQ ID NO:1, deltorphin II SEQ ID NO:2 or combinations of deltorphins I SEQ ID NO:1 and II SEQ ID NO:2 may be administered. A deltorphin concentration in the range of about 0.5 mg/kg to about 20 mg/kg in a physiologically acceptable formulation blocks a cytokine cascade in a murine model of septic shock. A therapeutic method of modulating cytokine mediated acute inflammatory, trauma induced and toxin induced hepatic injury, particularly via tumor necrosis factor modulation, is thus disclosed. |
申请公布号 |
ZA200005924(B) |
申请公布日期 |
2002.12.23 |
申请号 |
ZA20000005924 |
申请日期 |
2000.10.23 |
申请人 |
UNIVERSITY OF KENTUCKY RESEARCH FOUNDATION |
发明人 |
PETER R. OELTGEN;CRAIG I. MCCLAIN;SHIRISH BARVE |
分类号 |
C12N1/20;A61K38/00;A61K38/08;A61P1/16;A61P43/00;C07K14/46 |
主分类号 |
C12N1/20 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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