发明名称 Karbamater avledet fra arylalkylaminer
摘要 The invention relates to carbamates having general structure (I), wherein: R1, R2 and R3 are H, OH, SH, CN, F, Cl, Br, I, (C1-C4)-alkylthio, (C1-C4)-alkoxyl, (C1-C4)-alkoxyl substituted by one or several F radicals, carbamoylamine, (C1-C4)-alkyl and (C1-C4)-alkyl substituted by one or several F or OH radicals; R4 represents a substituted or non-substituted cycloalkyl or cycloaryl radical (a heteroalkyl radical or not). The amine of the quinuclidine ring can also be forming quaternary ammonium salts or in an oxidized state (N-oxide). Carbamates (I) are antagonists of the M3 muscarinic receptor, and selectively, the M2 receptor. Hence, they can be used in the treatment of urinary incontinence (particularly due to bladder instability), irritable bowel syndrome, diseases of the respiratory tract (particularly chronic obstructive pulmonary disease, chronic bronchitis, asthma, emphysema and rhinitis) and in ophthalmologic operations.
申请公布号 NO20026211(D0) 申请公布日期 2002.12.23
申请号 NO20020006211 申请日期 2002.12.23
申请人 LABORATORIOS SALV AT SA 发明人 GALLEMI, CARLES FARRERONS;RUIZ, JUAN LORENZO CATENA;SERRAT, ANNA FERNANDEZ;BONO, IGNACIO JOSE MIQUEL;LOPEZ, DOLORS BALSA;NAVARRO, JOSE IGNACIO BONILLA;ARNAL, CARMEN LAGUNAS;ROCA, CAROLINA SALCEDO;GARCIA, ANDRES FERNANDEZ
分类号 A61K31/439;A61P1/00;A61P11/00;A61P11/02;A61P13/00;A61P13/10;A61P27/02;A61P43/00;C07D453/02;(IPC1-7):C07D 主分类号 A61K31/439
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