| 摘要 |
A compound of formula (1.0.0), wherein: A is aryl, heteroaryl, or heterocyclyl; wherein the aryl, heteroaryl, or heterocyclyl is substituted with 0 to 3 R10, or is a member selected from the group consisting of divalent radicals: -A1-NHC(=O)NH-A2-, -A1-NHC(=O)O-A2-, and -A1-NH(NCN)NH-A2-, wherein A1 and A2 are each independently selected from the group consisting of hydrogen, aryl, heteroaryl, and heterocyclyl, wherein the aryl heteroaryl or heterocyclyl is substituted with 0 to 3 R10, B is described herein, E is a single bond, -O-, -CH=CH-, or a moiety of formula (1.9.0) described herein, Y is -C(=O)-, -C(=S)-, -S(=O)2-, or -CH(Ra)-, m is an integer independently selected from 0, 1 and 2, n is an integer independently selected from 1 and 2, p is an integer independently selected from 1 and 2, and R is independently selected from the group consisting of -tetrazolyl, -C(=O)OR5, C(=O)NHS(=O)2R6, and a moiety of formula (3.0.0) described herein. Also described is the use of the compounds of formula (1.0.0) in the manufacture of a medicament for treating or preventing an inflammatory, autoimmune or respiratory diseases by inhibiting cell adhesion and associated pathogenic processes mediated by VLA-4.
|
