| 摘要 |
A derivative of pyrazoline of general formula (I), wherein: R1 represents hydrogen, methyl, fluoromethyl, difluoromethyl, trifluoromethyl, carboxylic acid, C1-C4 carboxylate, carboxamide or cyano group, R2 represents hydrogen atom or methyl, R3, R4, R7 and R8, identical or different represent hydrogen, chlorine, fluorine, methyl, trifluoromethyl or methoxy, One of R5 and R6 represents hydrogen, chlorine, fluorine, methyl, trifluoromethyl, methoxy or trifluoromethoxy, and the other of R5 and R6 is methylsulphonyl, aminosulphonyl or acetylaminosulphonyl, with the proviso that when R1 represents a methyl group, then: R2 represents hydrogen or methyl, R3 and R8, identical or different, represent hydrogen, chlorine, fluorine, methyl or trifluoromethyl, R4 represents hydrogen, fluorine, methyl, trifluoromethyl or methoxy, one of R5 and R6 represents fluorine, trifluoromethyl or trifluoromethoxy, and the other of R5 and R6 is a methsulphonyl or aminosulphonyl, and R7 represents hydrogen, chlorine, fluorine, methyl, trifluoromethyl or methoxy. The derivatives are useful for the treatment of inflammation.
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