Treatment of obesity using hGH 177-191analogues

摘要

A isolated peptide which comprises an analogue of the carboxyl-terminal sequence of a growth hormone. The carboxy-terminal sequence contains amino acid residues 177-191 of human growth hormone: Leu-Arg-lle-Val-Gln-Cys-Arg-Ser-Val-Glu-Gly-Ser-Cys-Gly-Phe, or a corresponding sequence of a non-human mammalian growth hormone. The analogue comprises (i) amino acids at positions 182 and 189 of hGH are joined by a bond to promote a cyclic conformation; and/or (ii) amino acids at positions 183 and 186 of hGH are joined by a salt bridge or a covalent bond; or an organic or inorganic acid addition salt thereof.