| 摘要 |
FIELD: organic chemistry, medicine, pharmacy. SUBSTANCE: invention relates to novel derivatives of cycloalkanopyridine of the general formula (I) where A means unsubstituted aryl with 6-10 carbon atoms or aryl substituted with phenyl, nitro-group, halogen atom, trifluoromethyl group or trifluoromethoxy-group or residue of the formula given in the invention claim; E means cycloalkyl with 3-8 carbon atoms, linear or branched alkyl with 1-8 carbon atoms or unsubstituted phenyl or phenyl substituted with halogen atom or trifluoromethyl group; R1 and R2 form in common linear or branched alkylene chain with 1-7 carbon atoms that is substituted with carbonyl group and/or residue of the formula given in the invention claim, mixture of their isomers or separate isomers, their salts and N- oxides with exception for 5(6H)-quinolone, 3-benzoyl-7,8-dihydro-2,7,7-trimethyl-4-phenyl. Also, invention discloses intermediate compounds used for synthesis of indicated derivatives of cycloalkanopyridine and pharmaceutical composition based on thereof. Invention can be used in medicine for treatment and prophylaxis of hypolipoproteinemia, dyslipidemia, hypertriglyceridemia, hyperlipidemia or arteriosclerosis. EFFECT: valuable medicinal properties of compounds. 6 cl, 5 tbl, 373 ex
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