| 摘要 |
A solid delayed-release formulation, intended to be placed in a body, containing at least one active principle and a biodegradable excipient, wherein the excipient is a polyactide-glycolide (PLGA) copolymer, the concentration of the active principle is over 40% and the excipient does not form a matrix containing the active principle, whereby the release profile of the active principle is constant and the duration of release is substantially greater in vivo than in physiological aqueous medium in vitro. A process of preparation of this delayed-release formulation is also described.
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