A topical formulation which induces a minimal systemic effect when applied to the skin, the topical formulation comprising an immunosuppressive macrolide selected from sirolimus, FK506 and SDZ ASM 981 and a permeation modulator for the treatment of a dermatological condition

摘要

A topical formulation for the treatment of a dermatological condition which comprises: i).An immunosuppressive macrolide selected from sirolimus, FK506, and SDZ ASM 981. ii).A permeation modulator selected from an alkanoic acid and an alkenic acid provided that when the immunosuppressive macrolide is FK506 the permeation modulator is not oleic acid. The permeation modulator and the macrolide are present in relative amounts such that when a therapeutic amount is applied to the skin a minimal systemic effect is produced. Also described is the use of an immunosuppressive macrolide selected from sirolimus, FK506, and SDZ ASM 981 in the preparation of the topical formulation described above.