TEST SYSTEM FOR CHARACTERIZING MODULATORS OF THE SPLICING PROCESS OF MRNA IN LIVING CELLS (IN VIVO), PRODUCTION THEREOF AND USE THEREOF

摘要

The invention relates to an in vivo test system containing the following: (a) at least one cellular in vivo system containing at least one spliceable nucleic acid containing at least one intron; (b) the nucleic acid in (a) being spliced and the mRNA being translated; (c) and a detectable signal being induced; (d) in the presence of at least one interesting substance; (e) optionally, other auxiliary agents.