PROCESS AND APPARATUS FOR PRODUCTION OF F-18 FLUORIDE

摘要

A process and apparatus for producing the <18>F isotope from water enriched with the <18>O isotope using high energy protons a cyclotron. The apparatus has a cyclotron target cavity (11) that is connected to a target loop (L1) that contains a water reservoir (15), pump (13), and pressure regulator (27). Water is continuously recirculated through the target cavity to increase reliability. After irradiation long enough to produce a desired amount of <18>F, water in the target loop (L1) is diverted through an <18>F extraction device (C1) before being returned to the target loop. Preferably, the returning water is purified and additional water may be added to the target loop as needed to permit continuous irradiation and production of <18>F.