PROCESS FOR THE PRODUCTION OF ZALEPLON

摘要

The present invention provides a process for the production of N-[3(3- cyanopyrazolo[1,5-a]pyrimidin-7-yl)phenyl]-N-ethylacetamide (zaleplon), an active ingredient that is approved for the treatment of insomnia. The proces s involves reacting N-[3-[3-(dimethylamino)-1-oxo-2-propenyl]phenyl]-N- ethylacetamide or a salt thereof with 3-amino-4-cyanopyrazole or a salt thereof under acidic conditions in a reaction medium comprising a mixture of water and a water-miscible organic compound.