发明名称 |
A G-PROTEIN COUPLED RECEPTOR AND USES THEREFOR |
摘要 |
The present invention is based on the identification of a G-protein coupled receptor (GPCR) that is expressed predominantly in the brain and placenta an d nucleic acid molecules that encoded the GPCR, which is referred to herein as the hCAR protein and hCAR gene respectively (for human Constitutively Active Receptor). Based on this identification, the present invention provides: (1) isolated hCAR protein; (2) isolated nucleic acid molecules that encode an hC AR protein; (3) antibodies that selectively bind to the hCAR protein; (4) metho ds of isolating allelic variants of the hCAR protein and gene; (5) methods of identifying cells and tissues that express the hCAR protein/gene; (6) method s of identifying agents and cellular compounds that bind to the hCAR protein; (7) methods of identifying agents that modulate the expression of the hCAR gene; and (8) methods of modulating the activity of the hCAR protein in a ce ll or organism.
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申请公布号 |
CA2449649(A1) |
申请公布日期 |
2002.12.19 |
申请号 |
CA20022449649 |
申请日期 |
2002.05.30 |
申请人 |
WYETH COMPANY |
发明人 |
PAULSEN, JANET ELIZABETH;BLATCHER, MARIA;BATES, BRIAN GAITHER |
分类号 |
A01K67/027;A61K31/7088;A61K38/00;A61K39/395;A61K45/00;A61K48/00;A61P3/00;A61P9/00;A61P25/00;A61P35/00;A61P37/02;A61P43/00;C07K14/52;C07K14/705;C07K16/28;C12N1/15;C12N1/19;C12N1/21;C12N5/10;C12N15/00;C12N15/09;C12P21/02;C12Q1/68;G01N33/53;G01N33/566;(IPC1-7):C12N15/12;A01K67/00;C12Q1/02;A61K31/708;C12N15/85 |
主分类号 |
A01K67/027 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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