发明名称 CD10-ACTIVATED PRODRUG COMPOUNDS
摘要 The compounds of the invention are modified forms of therapeutic agents. A typical prodrug compound of the invention comprises a therapeutic agent, an oligopeptide, a stabilizing group and, optionally, a linker group. The prodrug is cleavable by the CD10 enzyme. Methods of treatment using the prodrug and methods of designing a prodrug are also disclosed.
申请公布号 WO02100353(A2) 申请公布日期 2002.12.19
申请号 WO2002US21135 申请日期 2002.06.11
申请人 MEDAREX, INC.;BEBBINGTON, CHRISTOPHER, R.;NIEDER, MATTHEW, H.;CARDARELLI, PINA, M.;GANGWAR, SANJEEV;PICKFORD, LESLEY, B.;PAN, CHIN 发明人 BEBBINGTON, CHRISTOPHER, R.;NIEDER, MATTHEW, H.;CARDARELLI, PINA, M.;GANGWAR, SANJEEV;PICKFORD, LESLEY, B.;PAN, CHIN
分类号 A61K31/704;A61K45/00;A61K47/48;A61K49/00;A61P35/00;A61P35/02;A61P35/04;A61P43/00;C07K5/06;C07K5/083;G01N33/68 主分类号 A61K31/704
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