DETERMINATION OF BONE-SIALOPROTEIN IN BODILY FLUIDS FOR ONCOLOGICAL PROBLEMS

摘要

The invention relates to antibodies or a plurality of antibodies directed against the human bone-sialoprotein. The invention is characterised in that the antibodies bind to epitopes, which are only present in the human bone-sialoprotein from tumour cells, the post-translational glycosylation of said protein in the region of the amino acids 120 to 135, containing the amino acids TGLAA, being modified or incomplete in comparison to normal bone-sialoprotein from bones. The antibodies are used in an immuno-assay for the diagnosis and prognosis of tumorous diseases, in particular for the diagnosis and prognosis of the bone metastases of a primary mammary carcinoma.