发明名称 |
Antigen presenting cells, a process for preparing the same and their use as cellular vaccines |
摘要 |
The invention relates to monocytes derived antigen presenting cells (MD-APCs) characterized in that they have the following properties: they present on their surface: antigen CD14 and CD64 with a mean intensity of about 5 to about 200; antigen CD80 and CD86 with a mean intensity of about 20 to about 200; antigen CD40 and mannose receptor with a mean intensity of 50 to 500; they are substantially devoid of the surface antigens CD1a and CD1c; they present a phagocytosis property; and they have the property of stimulating the proliferation of allogenic lymphocytes.
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申请公布号 |
US2002192193(A1) |
申请公布日期 |
2002.12.19 |
申请号 |
US20020195066 |
申请日期 |
2002.07.15 |
申请人 |
I.D.M. IMMUNO-DESIGNED |
发明人 |
CHOKRI MOHAMED;BARTHOLEYNS JACQUES;ROMET-LEMONNE JEAN-LOUP |
分类号 |
G01N33/53;A61K31/00;A61K31/415;A61K31/4164;A61K31/417;A61K35/12;A61K35/14;A61K38/00;A61K39/00;A61K39/02;A61K45/00;A61P37/00;A61P37/04;C07K14/705;C07K16/46;C12N5/02;C12N5/0786;C12N5/10;C12N15/09;C12P21/02;(IPC1-7):A61K45/00 |
主分类号 |
G01N33/53 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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