| 发明名称 |
NOVEL PROCESS FOR PREPARING RAC-BICALUTAMIDE AND ITS INTERMEDIATES |
| 摘要 |
The present invention relates to a new process for the synthesis of racemic and optically active bicalutamide starting from ethyl pyruvate and methyl methacrylate. The present invention discloses processes of preparing bicalutamide intermediates including ethyl-[2-{4-fluorophenyl sulfone}]-2-hydroxy propionate, 1,2-epoxy-2-methyl propionate and 2-hydrox-2-methyl-3-(4-fluorophenylthio) propionic acid. The present invention further discloses micronized rac-bicalutamide and the preparation thereof. |
| 申请公布号 |
WO02100339(A2) |
申请公布日期 |
2002.12.19 |
| 申请号 |
WO2002US18329 |
申请日期 |
2002.06.13 |
| 申请人 |
TEVA PHARMACEUTICAL INDUSTRIES LTD.;TEVA PHARMACEUTICALS USA, INC.;DOLITZKY, BEN-ZION;REANY, OFER;SHAMAI, JENNY |
发明人 |
DOLITZKY, BEN-ZION;REANY, OFER;SHAMAI, JENNY |
| 分类号 |
C07C69/675;C07C231/02;C07C231/08;C07C255/49;C07C255/50;C07C255/58;C07C315/04;C07C317/14;C07C317/44;C07C317/46;C07C317/48;C07C317/50;C07C319/14;C07C323/52;C07F1/02 |
主分类号 |
C07C69/675 |
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