NOVEL PYRAZINONE DERIVATIVES

摘要

Compounds of the general formula (I) or pharmaceutically acceptable salts or esters thereof; pharmaceutical compositions, inhibitors against Cdk4 and/or Cdk6, or anticancer drugs, containing the compounds, the salts or the esters as the active ingredient; and processes for the preparation of them wherein Ar1 is aryl fused to the adjacent pyrazinone ring at its 5- and 6-positions, or the like; X is CO or the like; Y is CH or the like; Z is CH or the like; V is CH or the like; Wn is (CH2)n- (wherein n is 0 to 4); R1 is hydrogen, optionally substituted lower alkyl, or the like; R2 is hydrogen or the like; R3 and R4 are each independently hydrogen or the like; and R5 and R6 are eac h independently hydrogen, hydroxyl, or the like.