Transdermal and topical administration of bone density regulators using basic enhancers

摘要

Methods are provided for enhancing the permeability of skin or mucosal tissue to topical or transdermal application of bone density regulators. The methods entail the use of a base in order to increase the flux of the bone density regulator through a body surface while minimizing the likelihood of skin damage, irritation or sensitization. The permeation enhancer can be an inorganic or organic base. Compositions and transdermal systems are also described.