| 摘要 |
The present invention is directed to substituted 3-aryl-5-aryl-[1,2,3]-oxadiazoles and analogs thereof, represented by the Formula I: wherein Ar1, Ar3, A, B and D are defined herein. The present invention also relates to the discovery that compounds having Formula I are activators of caspases and inducers of apoptosis. Therefore, the activators of caspases and inducers of apoptosis of this invention may be used to induce cell death in a variety of clinical conditions in which uncontrolled growth and spread of abnormal cells occurs. |
| 申请人 |
CYTOVIA, INC.;CAI, SUI, XIONG;ZHANG, HAN-ZHONG;DREWE, JOHN, A.;REDDY, P., SANJEEVA;KASIBHATLA, SHAILAJA;KUEMMERLE, JARED, DANIEL;OLLIS, KRISTIN, P. |
发明人 |
CAI, SUI, XIONG;ZHANG, HAN-ZHONG;DREWE, JOHN, A.;REDDY, P., SANJEEVA;KASIBHATLA, SHAILAJA;KUEMMERLE, JARED, DANIEL;OLLIS, KRISTIN, P. |
