CYP450-SPECIFIC DNA PROBES AND PRIMERS, AND BIOLOGICAL APPLICATIONS THEREOF

摘要

The present application relates to a set of new cDNA probes which enables th e specific and simultaneous detection of the main fourteen CYP450 isoforms, an d to new primers specific to the probes. It also provides transfection vectors , genetically engineered cells, and with amplification products derived therefrom. The present application notably encompasses any solid surface suc h as DNA filters or DNA chips which comprises a cDNA probe or an amplification product of the invention. The products provided thereby enables to evaluate the toxicity or pathogenicity of a product, and to predict drug in vivo interactions or efficiency.