Methods for preparing purified oligonucleotides by treating a solution comprising an oligonucleotide with an aggregating agent and a precipitation enhancer under conditions sufficient to form an oligonucleotide aggregate and isolating the oligonucleotide to produce a purified oligonucleotide.
申请公布号
WO02100873(A1)
申请公布日期
2002.12.19
申请号
WO2002US17915
申请日期
2002.06.05
申请人
ISIS PHARMACEUTICALS, INC.;MOORE, MAX, N.;ARTHUR, JOHN, CHARLES;VANSOOY, KENT;SCOZZARI, ANTHONY, N.
发明人
MOORE, MAX, N.;ARTHUR, JOHN, CHARLES;VANSOOY, KENT;SCOZZARI, ANTHONY, N.
