发明名称 |
Antagonism of endothelin actions |
摘要 |
The mechanism of hypertension following acute NO synthase blockade is via endothelin-mediated vasoconstriction. Thus, NO appears to inhibit endothelin activity by blocking its expression and not as a chronic direct acting vasodilator. Administration of an endothelin antagonist to a patient in a "normal' physiological state may result in specific regional vasodilation. This treatment finds utility in the treatment of erectile dysfunction.
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申请公布号 |
US2002193307(A1) |
申请公布日期 |
2002.12.19 |
申请号 |
US20020097206 |
申请日期 |
2002.03.11 |
申请人 |
QUEEN'S UNIVERSITY AT KINGSTON |
发明人 |
BANTING JAMES D.;HEATON JEREMY P.W.;ADAMS MICHAEL A. |
分类号 |
A61K45/00;A61K31/505;A61K31/661;A61K31/7088;A61K38/00;A61K38/14;A61K38/22;A61K38/55;A61K45/06;A61K48/00;A61P9/00;A61P15/10;A61P43/00;(IPC1-7):A61K38/17;A61K31/513 |
主分类号 |
A61K45/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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