发明名称 |
PROCESS FOR THE PREPARATION OF PAROXETINE SUBSTANTIALLY FREE OF ALKOXY IMPURITIES |
摘要 |
The present invention is directed to methods for preparing intermediates useful in the synthesis of paroxetine wherein the intermediates are substantially free of alkoxy impurities as well as to methods for preparing paroxetine and pharmaceutically acceptable salts thereof substantially free of alkoxy impurities. The alkoxy impurity is reacted with an ether cleaving agent to generate to corresponding phenol, which is separated, yielding the desired product substantially free of alkoxy impurities. Paroxetine intermediates such as PMA, paroxetine, and pharmaceutically acceptable salts thereof substantially free of alkoxy impurities also form part of the present invention. |
申请公布号 |
WO02100829(A2) |
申请公布日期 |
2002.12.19 |
申请号 |
WO2002US21106 |
申请日期 |
2002.06.13 |
申请人 |
TEVA PHARMACEUTICAL INDUSTRIES LTD.;TEVA PHARMACEUTICALS USA, INC.;NIDDAM, VALERIE;AVRUTOV, ILYA |
发明人 |
NIDDAM, VALERIE;AVRUTOV, ILYA |
分类号 |
C07D211/22;C07D405/12 |
主分类号 |
C07D211/22 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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