COMPOSITIONS AND METHODS FOR ENHANCING NUCLEIC ACID TRANSFER INTO CELLS

摘要

The present invention relates to compositions and methods for enhancing nucleic acid transfer into cells and especially for enhancing nucleic acid transfer into cells for which conventional non-viral transfection methods and compositions are inefficient. More specifically, the present invention is concerned with nucleic acid delivery compositions and methods comprising cationic polymers. The present invention particularly relates to compositions and methods for transfecting cells using a nucleic acid-cationic polymer-lipid mixture. The compositions and methods of the present invention display significantly improved transfection efficiency over other non-viral delivery formulations and methods.