发明名称 |
UNIMOLECULAR POLYMERIC MICELLES WITH AN IONIZABLE INNER CORE |
摘要 |
The present invention describes the preparation of unimolecular polymeric micelles (UPM) that bear a hydrophilic shell and a potentially ionizable and relatively hydrophobic core at a determined pH value. The core becomes electrostatically charged as the pH is changed. Such micelles can be made fr om either biodegradable or non-biodegradable polymers. Loaded drugs can be physically retained in the micelles when the pH of the surrounding medium favors interactions with the core. Upon a change in pH, modification in the ionization state of the core will decrease the interactions between the drug and the inner core and facilitate the release of the micellar contents.</SDO AB>
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申请公布号 |
CA2452813(A1) |
申请公布日期 |
2002.12.19 |
申请号 |
CA20022452813 |
申请日期 |
2002.06.07 |
申请人 |
LABOPHARM, INC.;LABOPHARM (BARBADOS) LIMITED;LABOPHARM EUROPE LIMITED |
发明人 |
RANGER, MAXIME;LEROUX, JEAN-CHRISTOPHE |
分类号 |
A61K9/127;A61K9/51;A61K47/30;A61K47/48;B01J13/02;(IPC1-7):B01J13/02;A61K9/50 |
主分类号 |
A61K9/127 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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