PROCESS FOR THE PRODUCTION OF N-[3-(3-CYANOPYRAZOLO[1,5-A] PYRIMIDIN-7-YL)PHENYL]-N-ETHYLACETAMIDE (ZALEPLON)

摘要

The present invention provides a process for the production of N-[3(3-cyanopyrazolo[1,5-a]pyrimidin-7-yl)phenyl]-N-ethylacetamide (zaleplon), an active ingredient that is approved for the treatment of insomnia. The process involves reacting N-[3-[3-(dimethylamino)-1-oxo-2-propenyl]phenyl]-N-ethylacetamide or a salt thereof with 3-amino-4-cyanopyrazole or a salt thereof under acidic conditions in a reaction medium comprising a mixture of water and a water-miscible organic compound.