A MOUSE UNABLE TO EXPRESS FUNCTIONAL ALPHA-4 INTEGRIN PROTEIN, AND METHODS FOR ASSAYING COMPOUNDS OR AGENTS FOR ALPHA-4 INTEGRIN PROTEIN ANTAGONIST ACTIVITY AND A GENETIC MARKER FOR EVALUATING EFFICACY OF MODULATORS OF SIGNALING ACTIVITY OF A VLA-4 RECEPTOR

摘要

Provided herein is a mouse that is unable to express functional alpha-4-integrin protein, and methods for assaying agents for alpha-4 integrin antagonist activity, as well as genetic markers for analyzing the efficacy of VLA-4 modulators, and particularly antagonists.